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Self-assembling nanoparticles composed of transmembrane peptides and their application for specific intra-tumor delivery of anti-cancer drugs
专利权人:
Nadya I. Tarasova
发明人:
Nadya I. Tarasova,Sergey G. Tarasov,Christopher J. Michejda
申请号:
US12513950
公开号:
US09326950B2
申请日:
2007.11.06
申请国别(地区):
US
年份:
2016
代理人:
摘要:
The invention provides a method of handling a hydrophobic agent, which method comprises (a) combining in an aqueous solution (i) a hydrophobic agent and (ii) an isolated peptide that is a structural analog of a transmembrane domain of an integral membrane protein, wherein one terminus of the peptide has one or more negatively charged residues, and (b) allowing the peptide to self-assemble into nanoparticles, wherein the nanoparticles comprise the hydrophobic agent.
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