CHARLES E. HART,CONAN S. YOUNG,LEO B. SNEL,VLADIMIR KERY
申请号：
BRPI0923015
公开号：
BRPI0923015A2
申请日:
2009.12.18
申请国别(地区):
BR
年份:
2015
代理人:
摘要：
The invention features bone grafts (such as bone allografts) with reduced protease activity. These bone grafts are useful, for example, in conjunction with a polypeptide of interest (such as platelet derived growth factor) for treating, stabilizing, preventing, and/or delaying a bone, periodontium, ligament, cartilage, or tendon condition in an individual (such as a human). Additionally, the invention provides methods of measuring the protease activity associated with a bone graft, reducing the level of protease activity associated with a bone graft, selecting a bone graft with an acceptable level of protease activity, and methods of administering a bone graft and a polypeptide of interest to an individual.
