RECOMBINANT BCG OVEREXPRESSSING phoP-phoR

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专利权人:

Jun Liu;Chengdu Yongan Pharmaceutical Co., Ltd.

发明人:

Jun Liu

申请号：

US16500934

公开号：

US20200254080A1

申请日:

2017.04.07

申请国别(地区):

US

年份:

2020

代理人:

摘要：

Provided are a live recombinant Mycobacterium bovis-BCG strain and a tuberculosis (TB) vaccine or immunogenic composition comprising a nucleic acid capable of overexpression, the nucleic acid encoding PhoP and PhoR proteins. A method for treatment or prophylaxis of a mammal against challenge by Mycobacterium tuberculosis or Mycobacterium bovis using the strain is also provided.

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