It is intended to provide a novel polypeptide having an activity of growing vascular endothelial cells, an activity of promoting transcription form c-fos promoter, an activity of promoting transcription from VEGF promoter and/or an angiogenic activity a polynucleotide encoding this polypeptide the above polypeptide and/or a pharmaceutical composition containing the polypeptide for treating a disease selected from the group consisting of obstructive arteriosclerosis, Buerger s disease, peripheral vascular disorder, angina, myocardial infarction, brain infarction, ischemic heart disease and ischemic brain disease a method of treating these diseases and an antibacterial composition. The above problems can be solved by isolating a novel peptide having the above-described activities and a nucleotide encoding this peptide.
