A system for preventing delivery of less than a predetermined minimum dose of a medicament by providing a dose setting mechanism (104) having a clutch ring (130 200) rotationally fixed relative to the housing (120) when a dose less than the minimum allowable dose is selected. The dose setting mechanism also includes a drug delivery device housing (120) and a dose dial component (122 202) positioned in the housing and rotatable during a dose setting step. A drive sleeve(124 206) is positioned within the dose dial component, a spindle (126) is positioned within the drive sleeve, and a clutch (128 212) is positioned between the dose dial component and the drive sleeve. When the dose dial component is rotated to select a dose less than a minimum dose, a clutch ring (130 200) prevents the drive sleeve from rotating to thereby prevent the selected dose from being administered.
