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NOVEL IMINOSUGARS AND THEIR APPLICATIONS
专利权人:
发明人:
申请号:
EP13800188.8
公开号:
EP2858642A1
申请日:
2013.06.05
申请国别(地区):
EP
年份:
2015
代理人:
摘要:
Iminosugar compounds are described that have inbuilt delivery features by virtue of covalent incorporation of a tocopherol moiety, or alternative moieties that are analogs of tocopherol or select analogs of cholesterol, or its antagonist &ldquoEzitimibe&rdquo and are likely to have broad spectrum antiviral activity. The compounds differ from previous iminosugar compounds, even lipophillic ones, being more hydrophobic and resembling fats and oils in their partition behavior in vivo into lipid phases of lipoproteins, cellular lipid droplet organelles and biological membranes. These features confer a number of unique delivery attributes in vivo, favorable to the therapy of virus infections involving cells of the lymphoid system and the liver, in particular, but these features are also favorable in general for the treatment of virus infections of man and animals.
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