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Bioavailable diacylhydrazine ligands to modulate the expression of exogenous genes through an ecdysone receptor complex
专利权人:
Intrexon Corporation
发明人:
Hormann, Robert Eugene,Potter, David,Chortyk, Orestes,Tice, Colin,Carlson, Glenn,Meyer, Andrew,Opie, Thomas
申请号:
ES11193098
公开号:
ES2566366T3
申请日:
2004.02.27
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
A compound selected from the group consisting of: 5-methyl-2,3- N '- (3,5-dimethyl-benzoyl) -N' - (1-ethyl-2,2-dimethyl-propyl) -hydrazide dihydro-benzo [1,4] dioxin-6- carboxylic; 5-Methyl-2,3-dihydro-benzo [1,4] dioxin-6-carboxylic acid N '- (1-tert-butyl-butyl) -N' - (3,5-dimethyl-benzoyl) -hydrazide ; 5-Methyl-2,3-dihydro-benzo [1,4] dioxin 5-methyl-2,3-dihydro-benzo [1,4] dioxin N '- (1-tert-butyl-butyl) -N' - (3,5-dimethoxy-4-methyl-benzoyl) -hydrazide -6- carboxylic; 5-Ethyl-2,3-dihydro-benzo [1,4-dimethoxy-4-methylbenzoyl) -N '- (1-ethyl-2,2-dimethyl-propyl) -hydrazide [1,4] ] dioxin-6- carboxylic; N '- (3,5-dimethyl-benzoyl) -N' - (1-5-ethyl-2,3-dihydro-benzo [1,4] dioxin-6-carboxylic acid; N '- (1-tert-butyl) -butyl) -N'- (3,5-dimethyl-benzoyl) -hydrazide of 5-ethyl-2,3-dihydro-benzo [1,4] dioxin-6-carboxylic acid; N '- (1-tert- 5-ethyl-2,3-dihydro-benzo [1,4] dioxin-6- carboxylic acid butyl-butyl) -N '- (3,5-dimethoxy-4-methyl-benzoyl) -hydrazide; N- ( 3,5-Dimethyl-benzoic acid 1-ethyl-2,2-dimethyl-propyl) -N '- (3-methoxy-2-methylbenzoyl) -hydrazide; N- (1-ethyl-2,2-dimethyl- 3,5-dimethoxy-4-methyl-benzoic acid propyl) -N '- (3-methoxy-2-methyl-benzoyl) -hydrazide; N- (1-tert-butyl-butyl) -N' - (3 3-Methyl-2-methyl-benzoyl) -hydrazide of 3,5-dimethyl-benzoic acid; N- (1-tert-butyl-butyl) -N '- (3-methoxy-2-methylbenzoyl) -hydrazide of 3-acid , 3,5-dimethyl acid 5-dimethoxy-4-methyl-benzoic acid; N- (1-ethyl-2,2-dimethyl-propyl) -N '- (2-ethyl-3-methoxy-benzoyl) -hydrazide -benzoic acid; 3,5-dimethoxy-4-methyl-benzoic acid N- (1-ethyl-2,2-dimethyl-propyl) -N '- (2-ethyl-3-methoxy-benzoyl) -hydrazide; N - (1-tert-butyl-butyl) -N '- (2-ethyl-3- 3,5-dimethyl-benzoic acid methoxy-benzoyl) -hydrazide; 3,5-Dimethoxy-4-methyl-benzoic acid N-(1-tert-butyl-butyl) -N '- (2-ethyl-3-methoxybenzoyl) -hydrazide; 3,5-dimethyl-benzoic acid N- (1-tert-butyl-pentyl) -N '- (4-ethyl-benzoyl) -hydrazide; 3,5-dimethyl-benzoic acid N- (2,2-dimethyl-1-phenyl-propyl) -N '- (4-eth
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