Methods and apparatuses for measuring parameters based on the presence or absence of fluid at a plurality of fluid sensing zones in a disposable cassette are described herein. In an embodiment, a fluidic device includes a disposable cartridge including a fluid channel, an instrument configured to receive the disposable cartridge, the instrument including at least one sensor having a plurality of fluid sensing zones spaced along the fluid channel when the disposable cartridge is received by the disposable cartridge, each fluid sensing zone configured to determine a presence or absence of fluid at a respective portion of the fluid channel, and a control unit configured to determine at least one of a fluid volume, a volume displacement, a flow rate, a flow velocity or a volume ratio of gas bubbles of the fluid based on the presence or absence of the fluid at each of the fluid sensing zones.
