MET ANTIBODIES AND IMMUNOCONJUGATES AND USES THEREOF农业专利-农业学术服务平台

发明人:: CHITTENDEN, THOMAS,基德登汤玛士,基德登湯瑪士,DECKERT, JUTTA,德克犹大,德克猶大,HICKS, STUART WILLIAM,希克斯史都华威廉,希克斯史都華威廉,LAI, KATHARINE C.,赖凯萨琳 C,賴凱薩琳 C,PARK, PETER U.,帕克彼得 U,帕克彼得 U,RUI, LINGYUN,路林元,路林元,TAVARES,

摘要：: MET is a receptor tyrosine kinase found on the surface of tumor cells. The present invention includes anti-MET antibodies, forms and fragments, having superior physical and functional properties immunoconjugates, compositions, diagnostic reagents, methods for inhibiting growth, therapeutic methods, improved antibodies and cell lines and polynucleotides, vectors and genetic constructs encoding same.MET為在腫瘤細胞表面上發現之受體酪胺酸激酶。本發明包括具有優越物理及功能性質之抗MET抗體、形式及片段;免疫結合物、組合物、診斷試劑、抑制生長之方法、治療方法、改良之抗體及細胞株;以及編碼其之聚核苷酸、載體及基因構建體。