Methods for modulating de novo hepatic lipogenesis by modulating XBP-1 activity

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专利权人:

Ann-Hwee Lee;Laurie H. Glimcher

发明人:

Ann-Hwee Lee,Laurie H. Glimcher

申请号：

US12812811

公开号：

US08940479B2

申请日:

2009.01.14

申请国别(地区):

US

年份:

2015

代理人:

摘要：

The invention provides methods and compositions for modulating the expression, processing, post-translational modification, stability and/or activity of XBP-1 protein, or a protein in a signal transduction pathway involving XBP-I to treat dyslipidemias and steatosis disorders. The present invention also pertains to methods for identifying compounds that modulate the expression, processing, post-translational modification, and/or activity of XBP-I protein or a molecule in a signal transduction pathway involving XBP-1.

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中国工程科技知识中心

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http://www.ckcest.cn/home/