WICKS, Robert T.,ATALA, Anthony,NZOU, Goodwell,WICKS, Elizabeth E.
申请号：
EP17837743
公开号：
EP3494213A4
申请日:
2017.08.04
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
Provided herein is an in vitro model of the blood brain barrier. In some embodiments, the model includes: an endothelial cell layer, and brain tissue layer comprising neuronal cells, and optionally one or more of astrocytes, pericytes, oligodendrocytes, and microglia. In some embodiments, the model further comprises a porous membrane between said endothelial cell layer and the neuronal cell layer. A microfluidic device comprising the same and methods of use thereof are also provided.
