It include pharmaceutical preparation the present invention relates to percutaneous plaster, which includes Ropivacaine or opioid, and pharmaceutically acceptable adhesive includes the silicone or polyisobutene and the weight between 5 and 20 of at most 75% (weight ratio). The excipient mixture of %. The present invention is also related to prepare such pharmaceutical preparation, and uses this transdermal patch treatment pain (such as pain and/or neuropathic pain).