Jung Ju Kim;Woo Jeong Choi;Yang Gyu Choi;Young Chang Ah
发明人:
Yang Gyu Choi,Young Chang Ah,Woo Jeong Choi,Jung Ju Kim
申请号：
US12084014
公开号：
US08728514B2
申请日:
2006.10.23
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Disclosed is a transdermal preparation containing a hydrophobic drug. As a method of continuing the high drug permeation, it is used an unique hydrophilic polymer system in which the drug can be contained in a high concentration under no water environment, a solubility of the hydrophobic drug is decreased as the water is introduced to the patch from the skin, so that the drug is maintained at the saturation concentration even though the drug content is decreased as the drug is permeated to the skin. During the application of the transdermal preparation to the skin, it is possible to continuously permeate the high amount of drug, to maintain the sufficient adhesion during the use and to minimize the skin side effect, because the hydrophilic polymer absorbs the water from the skin. The hydrophilic polymer system can serve the function thereof through the hydrophobic adhesive layer capable of preventing the water quickly absorbed from the skin from being evaporated to the outside of the patch.
