WO 18/ 14083 4 Al (a) 9 0 Sulrobetsahat , N11, Sulfabetaine-based agar[ easjagatei k, (IV) (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 02 August 2018 (02.08.2018) WIP0 I PCT omit VIII °nolo 010 Ho VIII mil olo HIND oimIE (10) International Publication Number WO 2018/140834 Al (51) International Patent Classification: A61K 31/715 (2006.01) A61K 31/738 (2006.01) (21) International Application Number: PCT/US2018/015613 (22) International Filing Date: 27 January 2018 (27.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/451,629 27 January 2017 (27.01.2017) US (71) Applicant: CORNELL UNIVERSITY [US/US]； Center For Technology Licensing At, Cornell University ('ctl'), 395 Pine Tree Road, Suite 310, Ithaca, NY 14850 (US). (72) Inventors: MA, Minglin； Riley-Robb Hall 322, Cornell University, Ithaca, NY 14853 (US). LIU, Qingsheng； Ri- ley-Robb Hall 145, Cornell University, Ithaca, NY 14853 (US). (74) Agent: CHILDS, Carissa, R. et al.； LECLAIRRYAN, A PROFESSIONAL CORPORATION, 70 Linden Oaks, Suite 210, Rochester, NY 14625 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (
