低黏度、高濃度之依伏庫單抗調配物及其製備方法农业专利-农业学术服务平台

发明人:: SLOEY, CHRISTOPHER J.,斯洛伊　克里斯多福　J,KANAPURAM, SEKHAR,卡纳普瑞　席克哈,卡納普瑞　席克哈,BINABAJI, ELAHEH,比那巴吉　伊拉赫,CUI, HUANCHUN,古　欢俊,古　歡俊,CHAN, CHIO MUI,詹　乔慕,詹　喬慕,斯洛伊克里斯多福 J,卡纳普瑞席克哈,卡納普瑞席克哈,比那巴吉伊拉赫,古欢俊,古歡俊,詹乔慕,詹喬慕

摘要：: Provided herein are formulations of PCSK9-binding polypeptides, such as those comprising evolocumab, that comprise N-acetyl arginine and have reduced viscosities when compared to formulations lacking N-acetyl arginine. Provided herein are also methods of formulating such compositions that are advantageous in that they conserve certain components. Such formulations comprising PCSK9-binding polypeptides can be administered to patients to treat and/or prevent PCSK9-related diseases, conditions, and disorders.本文提供包含N-乙醯基精胺酸且當與缺乏N-乙醯基精胺酸之調配物相比時具有降低之黏度的PCSK9結合多肽調配物，諸如包含依伏庫單抗(evolocumab)之彼等調配物。本文亦提供調配該等組合物之方法，該等方法為有利的，因為其保存某些組分。該等包含PCSK9結合多肽之調配物可投與至患者以治療及/或預防PCSK9相關疾病、病狀及病症。