Harri JUKARAINEN,Jyrki PIHLAJA,Svante HOLMBERG,Tuula VALO,Anu-Liisa HONKA,Jenny HOLLAENDER
申请号：
US15544326
公开号：
US20180008536A1
申请日:
2016.01.20
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The invention is describing an intrauterine delivery system comprising non-steroidal anti-inflammatory (NSAID) and a progestogenic compound, containing anti-inflammatory active compound in the frame material and that the progestogenic compound is contained in a silicon based reservoir attached to the frame, wherein the frame consist of a thermoplastic material. A further object of the invention is to fabricate drug-containing T-intrauterine systems (I US) with the drug incorporated within the entire backbone of the medical device by using 3D printing technique, based on fused deposition modelling (FDM™). Indomethacin was used to prepare drug-loaded poly-caprolactone (PCL)-based filaments with different drug contents 5-40 wt %, namely 5%, 15% and 30% wt %: of Indomethacin.
