The invention relates to nitrooxyderivative of corticosteroids of general formula (I) and pharmaceutically acceptable salts or stereoisomers thereofR—(Z)a—Rx (I)wherein R is the corticosteroid residue of formula (II):wherein:R1 is OH, R2—CH3, or R1 and R2 are taken together to form a group of formula (III)R3 is Cl or F；R4 is H or F；wherein R1, R2, R3 and R4 can be linked to the correspondent carbon atoms of the steroidal structure in position α or β；with the proviso that:when R1 and R2 are the group of formula (III) then R3 is F and R4 is H or F；The compounds are useful in the treatment of respiratory diseases, inflammatory diseases, dermatological diseases and ocular diseases.
