The present disclosure provides stabilized sulforaphene compositions and uses thereof. The compositions include a stabilized sulforaphene, such as sulforaphene-cyclodextrin complex, that increases the efficacy, biological activity and stability of isolated sulforaphene. The present disclosure also includes pharmaceutical and nutraceutical compositions and methods for the treatment of mitochondrial disorders and muscular disorders. In addition, methods for increasing ATP and/or FAD production in cells by the administration of a stabilized sulforaphene are provided.