DUKE UNIVERSITY;NORTH CAROINA STATE UNIVERSITY; LLC;IMMUNOLIGHT;IMMUNOLIGHT, LLC
发明人:
WALDER, HAROLD,BOURKE, FREDERIC A., JR.,FATHI, ZAKARYAE,BEYER, WAYNE,OLDHAM, MARK,ADAMSON, JUSTUS,NOLAN, MICHAEL
申请号：
CA3013335
公开号：
CA3013335A1
申请日:
2017.02.02
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
A phosphor-containing drug activator and suspension thereof are provided. The suspension at least includes two or more phosphors capable of emitting ultraviolet and visible light upon interaction with x-rays. The two or more phosphors include Zn2SiO4:M12+and (3Ca3 (PO4)2Ca(F, CI)2:Sb3*, Mn2+) at a ratio NP-200:GTP-4300 of from 1:10 to 10:1, and each of the two phosphors have an ethylene cellulose coating and/or a diamond-like carbon coating. The suspension further includes a pharmaceutically acceptable carrier. A system for treating a disease in a subject in need thereof includes a) the above-noted suspension, b) a photoactivatable drug containing 8-methoxypsoralen (8-MOP or UVADEX) untethered from the two or more phosphors, c) one or more devices which infuse the photoactivatable drug and the suspension including the pharmaceutically acceptable carrier into a diseased site in the subject, and d) an x-ray source which is controlled to deliver a dose of x-rays to the subject for production of the ultraviolet light.
