A polypeptide is disclosed, the tumor associated antigen (TAA) on the surface of cancer cell and a NKG2D receptor is bundled in. In killing cell, for example, natural killer cells, T cells, natural killer T cells and gamma delta T cells surface, NKG2D receptors are expressed. In some cases, TAA is CS-1 or EGFRvIII. Polypeptide disclosed in the polynucleotides of coding is also disclosed, the vector including disclosed polynucleotides, and the host cell including disclosed vector. Also disclose the bivalent antibody including disclosed polypeptide. Also disclose the pharmaceutical compositions including disclosed antibody. Also disclose the method for the treating cancer in a main body using disclosed specific antibody.
