Methods of treating αvβ3 integrin-associated diseases by administering polypeptides selective for αvβ3 integrin

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专利权人:

Woei-Jer Chuang;Wen-Mei Fu;Mannching Sherry Ku;Yen-Lun Huang

发明人:

Woei-Jer Chuang,Wen-Mei Fu,Mannching Sherry Ku,Yen-Lun Huang

申请号：

US13035579

公开号：

US08183201B2

申请日:

2011.02.25

申请国别(地区):

US

年份:

2012

代理人:

摘要：

The invention provides disintegrin variants, and more specifically to disintegrin variants which are selective αvβ3 integrin antagonists for treatment and prevention of αvβ3 integrin-associated diseases. The present invention also relates to pegylated proteins, including proteins comprising a disintegrin variant having an RGD motif variant 48ARLDDL53. The invention also relates to the use of the polypeptides of the invention for the treatment and prevention of αvβ3 integrin-associated diseases.

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中国工程科技知识中心

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http://www.ckcest.cn/home/