A centrifuge bowl for continuous separation of whole blood comprises an outer body rotatable about a longitudinal axis of the centrifuge bowl and a top core located within and rotatable with the outer body, the top core being coaxial with the outer body and having a chimney extending through the top core along the longitudinal axis of the centrifuge bowl. A separation region is located between the top core and the outer body, rotation of the centrifuge bowl separating the whole blood within the separation region into a first blood component and a second blood component. An inlet port introduces whole blood into the centrifuge bowl. An inlet tube is fluidly connected to and extends distally from the inlet port and through the chimney, the inlet tube configured to introduce the whole blood into an introduction region. A bypass seal between an outer diameter of the inlet tube and an inner diameter of the chimney isolates the introduction region from the chimney. A first blood component outlet port draws a first blood component out of the centrifuge bowl. A first blood component extraction tube extends from the first blood component outlet port to a first blood component extraction region. A second blood component outlet port is fluidly connected to the separation region and draws a second blood component from the centrifuge bowl. A centrifuge bowl rotary seal is attached to the outer body and fluidly couples the inlet port, first blood component outlet port, and second blood component outlet port to the outer body.
