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THE PRODUCT IN THE FORM OF THE FILM AND THE METHOD OF ITS PREPARATION
专利权人:
НИТТО ДЕНКО КОРПОРЕЙШН (JP)
发明人:
АСАРИ Дайсуке (JP),ХОРИ Мицухико (JP),СИСИДО Такуя (JP)
申请号:
RU2011111666/15
公开号:
RU2011111666A
申请日:
2011.03.28
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. The preparative form in the form of a film, including! edible polymer soluble in water and a polar organic solvent and! particles of a drug insoluble in a polar organic solvent. ! 2. The preparative form in the form of a film according to claim 1, where the average particle size of the drug is 0.1-60 microns. ! 3. The formulation in the form of a film according to claim 1 or 2, wherein the edible polymer is solid at ordinary temperatures. ! 4. The formulation in the form of a film according to claim 1 or 2, wherein the edible polymer is polyvinylpyrrolidone and / or hydroxypropyl cellulose. ! 5. The preparative form in the form of a film according to claim 4, where the molecular weight of polyvinylpyrrolidone ranges from 2500 to 3000000.! 6. The preparative form in the form of a film according to claim 4, where the molecular weight of hydroxypropyl cellulose ranges from 10,000 to 1150000.! 7. The preparative form in the form of a film according to claim 4, where hydroxypropyl cellulose has a degree of substitution of hydroxypropoxy groups from 50 to 100%. ! 8. The preparative form in the form of a film according to claim 1 or 2, where the solubility parameter of the polar organic solvent is at least 9.7. ! 9. A method of obtaining a formulation in the form of a film comprising an edible polymer soluble in water and a polar organic solvent and particles of a drug insoluble in a polar organic solvent, comprising! obtaining a liquid dispersion of a drug containing an edible polymer, particles of the drug and a polar organic solvent; ! forming a liquid dispersion of the drug into a thin film and! drying a thin film.1. Препаративная форма в виде пленки, включающая ! растворимый в воде и полярном органическом растворителе съедобный полимер и ! частицы лекарственного средства, нерастворимого в полярном органическом растворителе. ! 2. Препаративная форма в виде пленки по п.1, где средний размер частиц лекарственного средства составляет 0,1-60 мкм. ! 3. Препаративная
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