An adjustable vascular compression device assists in achieving partial or full occlusion of a blood vessel when applied to a patients limb, for example, during or following a medical procedure. Pads on the device apply preferential compression to portions of the circumference of the limb so as to enable blood flow through adjacent blood vessels during the compression period. Further, rapid fastening, tightening, loosening and release is enabled by a single mechanism, and gradual adjustments to the tightness may be made without releasing said mechanism.