3-Phenyl-isoquinolin-1 (2H) -one derivatives as PARP-1 inhibitors

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专利权人:

ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ

发明人:

パペオ，ジャンルカ・マリアーノ・エンリコ,チルラ，アレッサンドラ,ダネッロ，マッテオ,スコラロ，アレッサンドラ,ズッコット，ファビオ,パペオ,ジャンルカ・マリアーノ・エンリコ,チルラ,アレッサンドラ,ダネッロ,マッテオ,スコラロ,アレッサンドラ,ズッコット,ファビオ

申请号：

JP2014542801

公开号：

JP6106182B2

申请日:

2012.11.20

申请国别(地区):

JP

年份:

2017

代理人:

摘要：

There are provided substituted 3-phenyl-isoquinolin-1(2H)-one derivatives which selectively inhibit the activity of poly(ADP-ribose) polymerase PARP-1 with respect to poly(ADP-ribose) polymerase PARP-2. The compounds of the present invention are therefore useful in treating diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.

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