LIPOXEN TECHNOLOGIES LIMITED;BAXTER INTERNATIONAL INC.;BAXTER HEALTHCARE S.A.
发明人:
JAIN SANJAY,GREGORIADIS GREGORY,DWIVEDI ARCHANA,NATH SRIJIT,SIEKMANN JUERGEN,HAIDER STEFAN,ROTTENSTEINER HANSPETER,TURECEK PETER
申请号：
NZ59760010
公开号：
NZ597600A
申请日:
2010.07.26
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
Disclosed is a method of conjugating polysialic acid (PSA) or a modified PSA (mPSA) to an oxidized carbohydrate moiety of a glycoprotein other than a blood coagulation protein comprising a carbohydrate group, comprising contacting the oxidized carbohydrate moiety with the PSA or mPSA under conditions that allow conjugation, wherein said PSA or mPSA contains an aminooxy group and an oxime linkage is formed between the oxidized carbohydrate moiety and the aminooxy group on the PSA or mPSA. Disclosed is a conjugated glycoprotein other than a blood coagulation protein comprising: (a) the glycoprotein； and (b) at least one aminooxy-PSA or -mPSA bound to the glycoprotein of (a), wherein said aminooxy-PSA or -mPSA is attached to the glycoprotein via one or more carbohydrate moieties.
