Zhaoyang Meng;Mehul F. Patel;Yang Nan;Panduranga Abdulla P. Reddy;Arshad Siddiqui
发明人:
Zhaoyang Meng,Arshad Siddiqui,Panduranga Abdulla P. Reddy,Mehul F. Patel,Yang Nan
申请号：
US14234837
公开号：
US20140171456A1
申请日:
2012.07.20
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to certain pyrazolo[1,5-a]pyrrolo[3,2-e]pyrimidine and dipyrazolopyrimidine compounds of Formula (I) as inhibitors of mammalian Target Of Rapamycin (mTOR) kinase, which is also known as FRAP, RAFT, RAPT or SEP. The compounds may be used in the treatment of cancer and other disorders where mTOR is deregulated. The present invention further provides pharmaceutical compositions comprising the pyrazolo[1,5-a]pyrrolo[3,2-e]pyrimidine or dipyrazolopyrimidine compounds.
