The present disclosure relates to a system and method capable of utilizing augmented reality and/or mixed reality to guide a user through the performance of a high-quality health-related examination. A head-mounted augmented reality device, smartphone, tablet or alternate display device allows the user to simultaneously view virtual exam guidance elements alongside real-world objects such as relevant anatomical landmarks or the exam detector. The virtual exam guidance elements are generated and/or updated in real-time based on pre-determined exam protocols as well as relevant data streams, such as data from cameras, sensors, the exam detector or other sources. The guidance elements are generated and/or positioned in 3D space in order to demonstrate to the user the preferred techniques or maneuvers that should be performed. In an exemplary embodiment, the system and method are designed for the performance of high-quality cardiac, venous, arterial, obstetric, genitourinary, abdominal or musculoskeletal ultrasound exams.