A syringe having an integral ampule is disclosed. The syringe includes a barrel defining a reservoir configured to store a fluid and a plunger defining an inner cavity. The plunger includes an ampule within the inner cavity, where the ampule seals the fluid. The plunger also includes a cap at a proximal end of the plunger that is configured to move distally relative to the plunger, and a first one-way valve at the distal end of the plunger. The distal movement of the cap relative to the plunger causes an opening within the ampule. A method of injecting a fluid within a patient using a syringe having an integral ampule is also disclosed.
