A system and method of obtaining and analyzing ultrasound images of a patient provides for the identification of specific tissue types in using the image data. A feature vector set of sub-regions of the region of interest is obtained, dimensionally reduced and evaluated using a heuristic to identify the tissue type. Where the tissue type is suitable for image standardization, the overall gray scale of the image is adjusted with respect to a predetermined gray scale for the identified tissue type. The image may be segmented and plaque regions identified and characterized. The characterized plaque and other parameters such as percent stenosis may be used to determine a risk score for the patient.
