Disclosed is a method of manufacturing a tablet (6) by press-forming powder in a mortar (1) using a pushing surface (9a) at the lower end of an upper pounder and a pushing surface (11a) at the upper end of a lower pounder. Concave forming grooves (2a) integrally linked to the upper and lower pushing surfaces (9a, 11a) are formed in the inner circumferential surfaces of mortar holes (2). The mortar can be divided into upper separable piece (7) and a lower separable piece (8) at the bottom portions of the forming grooves (2a). After a final fixed pounder, which is one of the upper and lower pounders, is fixed at a press-forming position at which the pushing surface (9a or 11a) is integrally linked to the corresponding forming groove (2a), a final pressing pounder, which is the other pounder, is moved to the press-forming position so that the tablet (6) is press-formed. When the tablet (6) is taken out of the mortar by separating the upper and lower separable pieces (7, 8), the tablet is taken out of a final fixed separable piece, which is the separable piece (7 or 8) adjacent to the final fixed pounder, and the final fixed pounder. Subsequently, the tablet is taken out of a final pressing separable piece, which is the separable piece (7 or 8) adjacent to the final pressing pounder.Linvention concerne un procédé de fabrication de comprimé (6) au moyen dun moulage par compression dune poudre à lintérieur dun mortier (1) à laide dune face de pression (9a) dextrémité inférieure dun pilon supérieur, et dune face de pression (11a) dextrémité supérieure dun pilon inférieur. Une rainure de moulage (2a) de surface incurvée concave raccordée en un seul tenant à chacune des faces de pression (9a, 11a) supérieure et inférieure, est formée sur la face périphérique interne dun trou de mortier (2). Le mortier est formé de sorte à être séparé, au niveau de la partie fond de ladite rainure de moulage (2a), en pièces séparables (7) côté supérieur et en pièces séparables (8) côté inféri
