JOHN LATHAM,DAVID G. WINKLER,JOHN SKONIER,DIANA SHPEKTOR,TRENTON HAYES,JAMES GAN
申请号：
PT04720380
公开号：
PT1608399E
申请日:
2004.03.12
申请国别(地区):
PT
年份:
2012
代理人:
摘要：
Compositions and methods are provided that relate to the unexpected specific association of (i) the TGF-beta binding protein sclerostin with the BMP antagonist protein chordin to form a complex, and of (ii) the TGF-beta binding protein sclerostin with the BMP antagonist protein noggin to form a complex, either of which complex is incapable of binding to a TGF-beta superfamily member such as a BMP. The invention provides isolated complexes for use in screening assays to identify agents that modulate bone mineralization, and offers other related advantages.
