The present invention relates to silent Fc variants of anti-CD40 antibodies and compositions and methods of use of said antibodies for treating pathological disorders such as autoimmune and inflammatory disorders and/or for preventing or reducing the risk of graft rejection in transplantation.本發明係關於抗-CD40抗體之靜默Fc變體,及使用該等抗體治療諸如自體免疫及發炎病症之病理性病症及/或預防移植中之移植物排斥或降低其風險的組合物及方法。