Disclosed are a use of a safe valve scaffold and a valve replacement device with the valve scaffold, wherein the valve scaffold comprises a tubular support net stent, and flared sections connected to the end of the support net stent, which are linked to all end nodes on the corresponding sides of the support net stent. The flared sections are located at a first release end of the valve scaffold. The external rims of the flared sections are surrounded by several curved support bars, wherein all the end nodes corresponding to support bar positions on the support net stent are linked to support bars. Due to improvements to the structure of the existing memory alloy self-expandable valve scaffold, rhombic vertices existing in isolation which are present in non-end region of the valve scaffold are removed. While maintaining the mechanical properties of the original structure, this prevents spines from appearing after the valve scaffold is compressed, thereby resolving the problem of sheathing canal damage caused by the spines.