FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA;UNIVERSITA DEGLI STUDI DI URBINO CARLO BO;UNIVERSITA DEGLI STUDI DI PARMA;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
The present invention provides compounds and pharmaceutical compositions for inhibiting N-acylethanolamine acid amidase (NAAA). Inhibition of NAAA is contemplated as a method to sustain the levels of palmitoylethanolamide (PEA) and oleylethanolamide (OEA), two substrates of NAAA, in conditions characterized by reduced concentrations of PEA and OEA. The invention also provides methods for treating inflammatory diseases and pain, and other disorders in which decreased levels of PEA and OEA are associated with the disorder.
