PROBLEM TO BE SOLVED: To provide a prophylactic and therapeutic agent for bone fracture and bone diseases as well as a bone growth enhancer, and to provide a prophylactic and therapeutic agent for bone fracture and bone diseases as well as a bone growth enhancer, combined with a bone fracture therapeutic agent and bone absorption inhibiting agent and/or bone growth enhancer, each of which comprises carbon dioxide as an active ingredient.SOLUTION: The invention provides a therapeutic or prophylactic agent for bone diseases by topical administration of carbon dioxide which is a transdermal administration by (1) a device for carbon dioxide external administration which is equipped with a sealing enclosure member which can seal a body surface from the open air, supplying means for supplying carbon dioxide to the interior of this sealing enclosure member, and an absorption auxiliary member which contains a medium dissolving carbon dioxide and helps the percutaneous absorption of carbon dioxide, in the interior of the sealing enclosure member, or (2) a device for carbon dioxide external administration which is equipped with a sealing enclosure member which can seal the open air from a body surface, supplying means for supplying carbon dioxide to the interior of this sealing enclosure member, and sweating promoting means to promote sweating on the body surface in the interior of the sealing enclosure member.COPYRIGHT: (C)2015,JPO&INPIT【課題】二酸化炭素を有効成分とする、骨折及び骨疾患の予防・治療剤、並びに骨成長促進剤、二酸化炭素を有効成分とする骨折治療剤と骨吸収抑制剤及び/もしくは骨形成促進剤との併用による、骨折及び骨疾患の予防と治療剤、並びに骨成長促進剤。【解決手段】(1)体表面を外気から密閉することができる密閉包囲材と、この密閉包囲材の内部に二酸化炭素を供給するための供給手段と、前記密閉包囲材の内部において、二酸化炭素を溶解する媒体を含み、二酸化炭素の経皮吸収を助ける吸収補助材と、を備えている二酸化炭素外用投与装置、又は、(2)体表面から外気を密閉することができる密閉包囲材と、この密閉包囲材の内部に二酸化炭素を供給するための供給手段と、密閉包囲材の内部の体表面での発汗を増進させる発汗増進手段と、を備えている二酸化炭素外用投与装置、による経皮投与である、二酸化炭素の局所投与による骨疾患治療又は予防剤。【選択図】なし
