The present invention provides a method for the treatment and/or prevention of bacterial infection in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided is an antibody binding to OmpA that can assay OmpA levels in a biological sample and detect or diagnose bacterial infection in central nervous system and/or peripheral blood circulation.本發明提供一種治療及/或預防哺乳動物之中樞神經系統及/或周邊血液循環細菌感染之方法,其包含投藥有效量的外膜蛋白A或其衍生物至該哺乳動物。本發明亦提供一種與OmpA結合之抗體,其可分析生物樣品中OmpA的量並檢測中樞神經系統及/或周邊血液循環之細菌感染。
