1- (3- (6,7-DIMETHOXYQUINAZOLIN-4-YLOXY) PHENYL) -3- (5- (1,1,1-TRIFLUOR-2-METHYLPROPAN-2-YL) ISOXAZOL-3-YL) UREA AS RAF CHINESE MODULATOR IN TREATMENT OF CANCER DISEASES

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专利权人:

Ambit Biosciences Corporation

发明人:

Abraham, Sunny,Campbell, Brian, T.,CHAO, Qi,Faraoni, Raffaella,Holladay, Mark, W.,LAI, Andiliy, G.,Rowbottom, Martin, W.,Setti, Eduardo,Sprankle, Kelly, G.,BHAGWAT, Shripad, S.

申请号：

DK15166141

公开号：

DK2947072T3

申请日:

2009.03.17

申请国别(地区):

DK

年份:

2017

代理人:

摘要：

Compounds, compositions and methods are provided for modulating the activity of RAF kinases, including BRAF kinase and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder mediated by RAF kinases. The compound is 1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea, having the structure or a pharmaceutically acceptable salt, solvate, clathrate or hydrate thereof.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/