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Oxazoline and isoxazoline derivatives as crac modulators
专利权人:
LUPIN LIMITED
发明人:
IRLAPATI NAGESWARA RAO,DESHMUKH GOKUL KERUJI,KARCHE VIJAY PANDURANG,JACHAK SANTOSH MADHUKAR,SINHA NEELIMA,PALLE VENKATA P.,KAMBOJ RAJENDER KUMAR
申请号:
NZ60957211
公开号:
NZ609572A
申请日:
2011.10.31
申请国别(地区):
NZ
年份:
2015
代理人:
摘要:
The disclosure relates to compounds of formula (I) along with processes for their preparation that are useful for treating, preventing and/or managing the diseases, disorders, syndromes or conditions associated with the modulation of calcium release-activated calcium (CRAC) channel. For example compounds such as N-(5-(5-(5,5-Dimethyl-4-oxo-4,5-dihydroisoxazol-3-yl)-2-methylphenyl)pyrazine-2-yl)-2,6-difluorobenzamide and N-(5-(5-(5,5-Dimethyl-4-oxo-4,5-dihydroisoxazol-3-yl)-2-methylphenyl)pyrazin-2-yl)-4-methyl-l,2,3-thiadiazole-5-carboxamide are suitable for treating inflammatory diseases, autoimmune diseases, allergic disorders, organ transplant, cancer and cardiovascular disorders, which are selected form asthma, psoriasis, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, psoriatic arthritis, chronic obstructive pulmonary disease (COPD), inflammatory bowel diseases, pancreatitis, peripheral neuropathy, multiple sclerosis (MS) and inflammation associated with cancer.
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来源网址:
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