Gallate derivatives of (-) - epigallocatechin to inhibit proteasome农业专利-农业学术服务平台

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Gallate derivatives of (-) - epigallocatechin to inhibit proteasome

专利权人:: The Hong Kong Polytechnic University;WAYNE STATE UNIVERSITY;UNIVERSITY OF SOUTH FLORIDA;McGill University

发明人:: CHAN, Tak-Hang,LAM, Wai-Har,CHOW, Larry Ming-Cheung,DOU, Qing Ping,KUHN, Deborah,KAZI, Aslamuzzaman,WAN, Sheng Biao,LANDIS-PIWOWAR, Kristin

申请号：: ES05779886

公开号：: ES2660339T3

申请日:: 2005.08.15

申请国别(地区):: ES

年份:: 2018

代理人:

摘要：: A compound having the formula: ** Formula ** wherein - R11, R12, R13, R21, R22, R2, R3 and R4 are each independently selected from the group consisting of -H and C1 to C10 acyloxy group ； - R5 is -H, and where one of the following conditions applies: (i) each of R11, R2 and R4 is -H and each of R12, R13, R21, R22 and R3 is an acetate group； or (ii) each of R11, R13, R2 and R4 is -H and each of R12, R21, R22 and R3 is an acetate group； or (iii) each of R11 and R13 is -H and each of R12, R21, R22, R2, R3 and R4 is an acetate group； or (iv) R11 is -H and each of R12, R13, R21, R22, R2, R3 and R4 is an acetate group； or (v) each of R11, R12, R13, R21 and R22 is an acetate group, R2 is an acetate group and each of R3 and R4 is -H； or (vi) each of R11, R12, R13, R21 and R22 is an acetate group, R3 is an acetate group and R2 and R4 is -H； or (vii) each of R11, R12, R13, R21, R22, R2 and R4 is an acetate group and R3 is -H, for use in proteasome inhibition.Un compuesto que tiene la fórmula:**Fórmula** en donde - R11, R12, R13, R21, R22, R2, R3 y R4 se seleccionan cada uno independientemente a partir del grupo que consiste en -H y grupo aciloxi C1 a C10； - R5 es -H, y en donde se aplica una de las siguientes condiciones: (i) cada uno de R11, R2 y R4 es -H y cada uno de R12, R13, R21, R22 y R3 es un grupo acetato； o (ii) cada uno de R11, R13, R2 y R4 es -H y cada uno de R12, R21, R22 y R3 es un grupo acetato； o (iii) cada uno de R11 y R13 es -H y cada uno de R12, R21, R22, R2, R3 y R4 es un grupo acetato； o (iv) R11 es -H y cada uno de R12, R13, R21, R22, R2, R3 y R4 es un grupo acetato； o (v) cada uno de R11, R12, R13, R21 y R22 es un grupo acetato, R2 es un grupo acetato y cada uno de R3 y R4 es -H； o (vi) cada uno de R11, R12, R13, R21 y R22 es un grupo acetato, R3 es un grupo acetato y R2 y R4 es -H； o (vii) cada uno de R11, R12, R13, R21, R22, R2 y R4 es un grupo acetato y R3 es -H, para uso en la inhibición del proteasoma.