The present invention includes compositions and drying methods for preserving sensitive bioactive materials, such as peptides, proteins, hormones, nucleic acids, antibodies, drugs vaccines, yeast, bacteria (probiotic or otherwise), viruses and/or cell suspensions, in storage. The compositions include a carbohydrates component and a glass enhancer component, wherein the carbohydrate component includes a mixture of di-, oligo- and polysaccharides and the glass enhancer includes ions of organic acid and protein hydrolysates. The composition is prepared by dispersing all the solid components in a solution and then snap-frozen to form small beads, strings or droplets. The preferred drying method of the frozen beads, strings or droplets is initiated by a short purging and structure stabilizing step of the frozen particles under a vacuum pressure of less than <；2000 mTORR followed by a primary drying step under vacuum pressure of more than >；2000 mTORR and at a desired temperature. During the secondary and final drying step of the material a full vacuum pressure and elevated temperature are applied, to achieve a final desirable water activity of the dry material.La présente invention concerne des compositions et des procédés de séchage pour préserver des matériels bioactifs sensibles, tels que des peptides, des protéines, des hormones, des acides nucléiques, des anticorps, des médicaments, des vaccins, des levures, des bactéries (probiotiques ou autres), des virus et/ou des suspensions cellulaires, pendant leur stockage. Les compositions contiennent un composant glucidique et un composant amplificateur de vitrification, le composant glucidique comprenant un mélange de di-, oligo- et poly-saccharides et l'amplificateur de vitrification comprenant des ions d'acide organique et des hydrolysats de protéines. La composition est préparée par la dispersion de tous les composants solides dans une solution, laquelle est ensuite congelée rapidement pour former de petites billes,
