WEBSTER, SCOTT PETER,SECKL, JONATHAN ROBERT,WALKER, BRIAN ROBERT,WARD, PETER,PALLIN, THOMAS DAVID,DYKE, HAZEL JOAN,PERRIOR, TREVOR ROBERT
申请号：
ES10755215
公开号：
ES2540547T3
申请日:
2010.09.14
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound selected from compounds of the following formula, and pharmaceutically acceptable salts, solvates and hydrates thereof: ** Formula ** in which: - W is independently -Y； - Y is independently -Y1, -Y2, -Y3, -Y4 or -Y5； - Y1 is independently -OH； - Y2 is independently Y2A, - -Y2B or -Y2c； - Y3 is independently -Y3A, -Y3B or -Y3C； - Y4 is independently -F, -Cl, -Br or -I； - Y5 is independently -CN； in which: - Y2A is independently -ORYA； - Y2B is independently -ORYB； - Y2C is independently -ORYC； - Y3A is independently -RYA； - Y3B is independently -RYB； - Y3C is independently -RYC； in which: each -RYA is independently saturated aliphatic C1-6 alkyl； each -RYB is independently halo-saturated aliphatic C1-6 alkyl； each -RYC is independently saturated aliphatic C1-6 hydroxy-alkyl； and in which: each of -J1, -J2, -J3 and -J4 is -H； or each of -J2 and -J4 is -H； and -J1 and -J3 taken together form -CH2- or -CH2CH2- or each of -J1 and -J3 is -H； and -J2 and -J4 taken together form -CH2- or -CH2CH2- or each of -J2 and -J3 is -H； and -J1 and -J4 taken together form -CH2- or -CH2CH2- and in which: - RN is independently -H or -RNN； - RNN is independently saturated aliphatic C1-6 alkyl； and in which: - RB1 is independently -H or -RBB； - RB2 is independently -H or -RBB； in which: each -RBB is independently -RBB1, -RBB2 or -RBB3； in which: -RBB1 is independently saturated aliphatic C1-6 alkyl, and is optionally substituted with one or more substituents selected from -F, -OH, -ORBBB, -OCH2F, -OCHF2, -OCF3, -NH2, -NHRBBB and -NRBBB2； wherein each -RBBB is independently saturated aliphatic C1-4 alkyl； each -RBB2 is independently -F, -Cl, -Br or -I； each -RBB3 is independently -CN；Un compuesto seleccionado entre compuestos de la siguiente fórmula, y sales, solvatos e hidratos farmacéuticamente aceptables del mismo:**Fórmula** en la que: - W es independientemente -Y； - Y es independientemente -Y1, -Y2, -Y3, -Y4 o -Y5； - Y1 es independientemente -OH； - Y2 es independientemente
