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COMPOSITIONS GLYCOPEPTIDIQUES ET LEURS UTILISATIONS
专利权人:
SUSSEX RESEARCH LABORATORIES INC.
发明人:
CLARK, KENNETH BRADY,SO, REMMICK,VUKIC, VANJA
申请号:
EP14869829
公开号:
EP3080142A4
申请日:
2014.12.09
申请国别(地区):
EP
年份:
2016
代理人:
摘要:
The present disclosure provides glycosylated oligopeptides having the sequence Palmitoyl-X1-Lys-X2-X3-Lys-X4-OH, where: X1 is: absent, Ser having a glycosylated side chain, or Asn having a glycosylated side chain; X2 is: Thr, Thr having a glycosylated side chain, Asn having a glycosylated side chain, or Ser having a glycosylated side chain; X3 is: Thr, or Thr having a glycosylated side chain; X4 is: Ser, or Ser having a glycosylated side chain. At least one of X1, X2, X3 and X4 is an amino acid having a glycosylated side chain. Each glycosylated side chain is, independently, glycosylated with a carbohydrate selected from the group consisting of: glucose, N-acetyl-glucosamine, galactose, N-acetyl-galactosamine, mannose, maltose, lactose, rhamnose, cellobiose, xylose, and fucose. Each hydroxyl group on the carbohydrate is, independently, OH or acetylated.
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