The invention relates to a process for the purification of Fc containing proteins. A process comprising at least three chromatographic purification steps i.e. protein A affinity chromatography, anion exchange chromatography and hydrophobic interaction chromatography. The invention relates to, in particular, a process wherein the chromatographic purification steps have been carried out in the following order (a) Protein A affinity chromatography, (b) anion exchange chromatography and (c) hydrophobic interaction chromatography. More specifically, the invention provides a robust and scalable downstream purification process for use in the manufacturing of p75 TNFR:Fc for human administration.
