Stephen S. YOO,Ezra M. CHUNG,Yong-Soo KIM,Mien-Chie HUNG,Chia-Wei LI,Seung-Oe LIM
申请号：
US15559513
公开号：
US20180118830A1
申请日:
2016.03.29
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Antibodies that bind specifically to glycosylated PD-L1 relative to unglycosylated PD-L1 are provided. Antibodies that recognize specific epitopes of glycosylated PD-L1 protein and can block the binding of PD-L1 to PD-1 are provided. In some aspects, PD-L1 polypeptides comprising glycosylated amino acid residues at amino and carboxy terminal positions of the PD-L1 extracellular domain are also provided. Methods for making and using such antibodies and polypeptides (e.g., for the treatment of cancer) are also provided.
