IL-15 mutants having antagonist activity

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专利权人:

Jérôme Bernard

发明人:

Jérôme Bernard,Ariane Plet,Yannick Jacques,Catherine Harb,Agnès Quemener,Erwan Mortier

申请号：

US12978115

公开号：

US09493533B2

申请日:

2010.12.23

申请国别(地区):

US

年份:

2016

代理人:

摘要：

The present invention relates to the identification of an epitope in human Interleukin-15 (IL-15) that is responsible for binding to the interleukin-15 receptor α-chain. Two IL-15 regions are involved in the formation of this epitope: the first region (44LLELQVISL52, peptide 1) corresponds to a sequence located in the B helix and the second (64ENLII68, peptide 2 or 64ENLIIL69, peptide 2a) to a sequence located in helix C. Muteins displaying agonist or antagonist properties are described, and may be useful as therapeutic agents.

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