Yung-hsi KAO,Ya-chu Tang,Hsin-huei Chang,Hui-chen Ku
申请号：
US13898524
公开号：
US20150045358A1
申请日:
2013.05.21
申请国别(地区):
US
年份:
2015
代理人:
摘要：
A pharmaceutical composition for treating disorders associated with insulin resistance is disclosed, and the composition comprises at least one inhibitor which is an effective agent to suppress endothelin-1-stimulated resistin gene expression through decreasing the endothelin-1-stimulated phosphorylation of proteins downstream of endothelin type A receptor, wherein the downstream signaling molecules comprise ERK1/2, JNKs, AKT, and STAT3 proteins, and wherein the inhibitor is selected from at least one antagonist of the endothelin type A receptor or downstream signaling proteins.
