Susan W. BARNETT,Jan ZUR MEGEDE,Indresh SRIVASTAVA,Ying LIAN,Karin HARTOG,Hong LIU,Catherine GREER,Mark SELBY,Christopher WALKER
申请号：
US13458232
公开号：
US20120269840A1
申请日:
2012.04.27
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to the efficient expression of HIV polypeptides in a variety of cell types, including, but not limited to, mammalian, insect, and plant cells. Synthetic expression cassettes encoding the HIV Gag-containing polypeptides are described, as are uses of the expression cassettes in applications including DNA immunization, generation of packaging cell lines, and production of Env-, tat- or Gag-containing proteins. The invention provides methods of producing Virus-Like Particles (VLPs), as well as, uses of the VLPs including, but not limited to, vehicles for the presentation of antigens and stimulation of immune response in subjects to whom the VLPs are administered.
