VANDERBILT UNIVERSITY;THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERNS AFFAIRS
发明人:
Brophy Colleen M.,Komalavilas Padmini,Cheung-Flynn Joyce,Hocking Kyle M.,Eagle Susan S.
申请号：
US201615277843
公开号：
US10149470(B2)
申请日:
2016.09.27
申请国别(地区):
美国
年份:
2018
代理人:
Parker Highlander PLLC
摘要：
The leading cause of graft failure is the subsequent development of intimal hyperplasia, which represents a response to injury that is thought to involve smooth muscle proliferation, migration, phenotypic modulation, and extracellular matrix (ECM) deposition. Surgical techniques typically employed for vein harvest—stretching the vein, placing the vein in low pH, solutions, and the use of toxic surgical skin markers—are shown here to cause injury. The invention therefore provides for non-toxic surgical markers than also protect against stretch-induced loss of functional viability, along with other additives. Devices and compositions for reducing physical stress or protecting from the effects flowing therefrom, also are provided.
