DAVID V. SCHAFFER,RYAN R. KLIMCZAK,JAMES T. KOERBER,JOHN G. FLANNERY,DENIZ DALKARA MOUROT,MEIKE VISEL,LEAH C.T. BYRNE
申请号：
PT12774323
公开号：
PT2699270T
申请日:
2012.04.20
申请国别(地区):
PT
年份:
2017
代理人:
摘要：
The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells, when administered via intravitreal injection, compared to wild-type AAV. The present disclosure further provides methods of delivering a gene product to a retinal cell in an individual, and methods of treating ocular disease.
